|LETTER TO EDITOR
|Year : 2021 | Volume
| Issue : 2 | Page : 96-97
Microscopic perivascular pseudorosettes in a child with fourth ventricular tumor
Thirunavukkarasu Arun Babu1, Padmapriya Balakrishnan2
1 Department of Pediatrics, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India
2 Indira Gandhi Medical College and Research Institute, Puducherry, India
|Date of Submission||20-May-2021|
|Date of Acceptance||17-Aug-2021|
|Date of Web Publication||22-Dec-2021|
Thirunavukkarasu Arun Babu
Department of Pediatrics, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Babu TA, Balakrishnan P. Microscopic perivascular pseudorosettes in a child with fourth ventricular tumor. Int J Clinicopathol Correl 2021;5:96-7
|How to cite this URL:|
Babu TA, Balakrishnan P. Microscopic perivascular pseudorosettes in a child with fourth ventricular tumor. Int J Clinicopathol Correl [serial online] 2021 [cited 2022 Jan 19];5:96-7. Available from: https://www.ijcpc.org/text.asp?2021/5/2/96/333396
Histopathology plays an important role in confirming the specific diagnosis in many cases of suspected intracranial neoplasms. We are reporting an atypical presentation of posterior fossa tumor with seizures in a child where the specific diagnosis was made by classic histopathology findings.
A 4-year-old female presented with episodes of jerky movements of upper and lower limbs with transient loss of consciousness and post episodic paralysis of limbs for 1 week. The child was conscious, alert, active, and afebrile. Central nervous system, respiratory and cardiac system examination was normal. Fundus examination showed bilateral papilloedema. MRI brain showed mixed intensity lesion of 3.5 cm × 3 cm arising from the floor of the fourth ventricle causing obstructive hydrocephalus. Hematological investigations were normal. Ventriculoperitoneal shunt for acute obstructive hydrocephalus was done to decrease raised intracranial pressure. Intraoperatively, the tumor was soft, friable, irregular, and gray-white arising from the floor of the fourth ventricle. Total resection of the tumor was attempted. Histopathological examination showed moderately cellular tumor composed of monomorphic cells with fibrillary cytoplasm, round-to-oval nucleus with salt and pepper chromatin. There were numerous perivascular pseudorosettes and areas of calcification [Figure 1] and [Figure 2]. There were no mitotic figures and features of anaplasia. Diagnosis of classic ependymoma WHO grade II was made based on the age of the child, site of the tumor and histopathological features.
|Figure 1: Photomicrograph showing moderately cellular tumor composed of monomorphous cells arranged diffusely and as perivascular pseudorosettes (H and E, ×400)|
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|Figure 2: Photomicrograph showing perivascular pseudorosette composed of the nuclear-free cytoplasmic fibrillary zone of tumor cells around capillaries with monomorphic round to oval nuclear and salt and pepper chromatin (H and E, ×400)|
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Ependymoma, medulloblastoma, juvenile pilocytic astrocytoma, and brainstem glioma are important differential diagnoses for posterior fossa mass in children. Posterior fossa tumors usually present with vomiting, headache, cerebellar signs (if located in the cerebellum), and hydrocephalus, while seizures as presenting symptoms are rare. Tumor cells resemble normal ependymal cells but are arranged in unique perivascular pseudorosettes. In pseudorosette formation, the tumor cell nuclei are located at a distance from a central vessel with delicate processes radiating toward the vessel wall.
In conclusion, we are presenting a child with posterior fossa ependymoma presenting with seizures which was diagnosed by classic histopathology findings.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient (s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initial s will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Iddrissu MI, Dakurah TK, Wepeba GK. Anaplastic ependymoma of the fourth ventricle causing obstructive hydrocephalus. Ghana Med J 2005;39:33-6.
Prasad KSV, Ravi D, Pallikonda V, Raman BVS. Clinicopathological study of pediatric posterior fossa tumors. J Pediatr Neurosci 2017;12:245-50.
Malhotra A, Rao S, Santhoshkumar R, Muralidharan N, Mitra S, Shetty S. Pigmented ependymoma of the fourth ventricle-a curious entity: Report of a rare case with review of literature. Int J Surg Pathol 2020;29:80-4.
[Figure 1], [Figure 2]