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Year : 2021  |  Volume : 5  |  Issue : 2  |  Page : 74-77

Clear-cell variant renal cell carcinoma with leiomyomatous stroma: World Health Organization new entity

Departments of Pathology and Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Correspondence Address:
Gagan Kumar Rangari
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Semicircle Road Number 4, Varanasi - 221 005, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijcpc.ijcpc_1_21

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Renal cell carcinoma (RCC) represents about 3% of all newly diagnosed cancers in the United States and accounts for 85% of renal cancers in adults. These are approximately 65,000 new cases per year and 13,000 deaths from the disease. RCC with leiomyomatous stroma is an emerging entity. The risk factor and etiology of RCC were obesity, smoking, hypertension, acquired cystic kidney disease, and occupational exposure like trichloroethylene. Most of the RCC are sporadic, 2%–4% have a familial cause. In this study, 62 years' male patient comes with flank pain, flank mass on the right side, and hematuria, on imaging shows solid and homogeneous to heterogeneous with cystic area and hemorrhage. Histopathological features show the nest of tumor cells with clear cytoplasm arranged in an alveolar and acinar pattern having conspicuous nucleoli surrounded by abundant vascular and smooth muscle stroma. On the basis of histological and immunohistochemistry studies, findings were suggestive of clear-cell RCC Grade 2 with leiomyomatous stroma.

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