• Users Online: 60
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2021  |  Volume : 5  |  Issue : 1  |  Page : 1-8

Human tissue studies in primary headache disorders: A scoping review

1 Medical Student, School of Medicine, University of Jordan, Amman, Jordan
2 Medical librarian, Mayo Clinic Arizona, Arizona, United States
3 Neuropathologist, Independent Contractor, Arizona, United States
4 Department of Neurology, Mayo Clinic, Arizona, United States

Correspondence Address:
Jonathan Helmsley Smith
Mayo Clinic, 13400 E Shea Boulevard, Scottsdale, AZ 85259
United States
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijcpc.ijcpc_17_20

Rights and Permissions

Background: Despite the identification of structures with putative pathophysiological significance in primary headache disorders (e.g., posterior hypothalamus in cluster headache) there appears to be a paucity of human tissue studies examining the neuropathology of these regions. Objective: To synthesize the extent and knowledge pertaining to direct human tissue analysis in primary headache disorders. Methods: Scoping literature review. Results: Of 2718 located articles, 15 were eligible for inclusion. These studies evaluated either migraine (9, 60%) or cluster headache (6, 40%). Approximately 75% were published before or during the era of the first edition of the International Classification of Headache Disorders. The most common study design was case-control (8, 53.3%), and the most commonly examined tissues equally included skin (3, 20%), muscle (3, 20%), and brain (3, 20%). Thematically, these manuscripts generally evaluated peripheral nervous and systemic pathology, as well as more targeted pathophysiological aspects, including mitochondrial and mast cell dysfunction. Conclusions: While interest in this type of study design appears to be waning, histopathological evaluation of human tissue provides unparalleled opportunity to reveal novel pathophysiological insight. Considerations for future study design and reporting of work involving human tissue is suggested based on our review.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded148    
    Comments [Add]    

Recommend this journal